Tirzepatide half-life

Tirzepatide has an elimination half-life of approximately 120 hours (about 5 days). Here is what that means for how long a single dose stays in your system.

Simple single‑compartment elimination model ((1/2)^t/t½): it ignores absorption, route, and individual variation, so treat it as a shape, not a measurement. In the Peptilot app this curve is stacked across your actual logged doses.

Clearance milestones

Milestone	Time after a single dose
50% eliminated	~5 days
75% eliminated	~10 days
90% eliminated	~17 days
~97% eliminated (≈5 half-lives)	~25 days

Evidence and source context

Regulatory status: FDA-approved prescription medicine in specific products and indications; product labels and availability vary by market.
Evidence status: Official prescribing information and a large human clinical evidence base.
Half-life context: The official label reports an elimination half-life of approximately five to six days after subcutaneous tirzepatide. The chart uses a single fixed value and cannot represent individual pharmacokinetics.

Primary and official sources

Zepbound (tirzepatide) prescribing informationU.S. Food and Drug Administration · Official label

Sources checked July 24, 2026 by the Peptilot editorial team. Independent medical review is pending; this page is educational and is not a treatment recommendation for Tirzepatide.

About Tirzepatide

Tirzepatide is a dual GIP and GLP-1 receptor agonist studied for glucose regulation in type 2 diabetes and for effects on appetite and body weight. Its long half-life supports commonly reported once-weekly use. This entry is informational and is not a recommendation to use the compound.

See the full Tirzepatide compound page or the Tirzepatide reconstitution calculator, or compare against other compounds on the half-life overview.

Questions, answered.

What is Tirzepatide's half-life?

Tirzepatide's elimination half-life is approximately 120 hours (about 5 days), based on published pharmacokinetic data. That means about half of a dose is eliminated in that time, half of the remainder in the next interval, and so on.

How long does Tirzepatide stay in your system?

Using the ~5-half-lives rule of thumb, a single dose of Tirzepatide is roughly 97% eliminated after ~25 days. Actual clearance varies with dose history, route, and individual metabolism — treat this as an educational estimate, not a measurement.

Do levels build up with repeated doses?

Yes — if a new dose lands before the previous one is eliminated, the remainders stack. With consistent dosing, estimated levels reach steady state after roughly four to five half-lives. Peptilot's Levels feature stacks this exact curve across your logged doses so you can see the estimate for your own history.

Educational information for people who track their protocols — not medical advice, and never a recommendation to use any compound. Always work with a qualified healthcare provider.

Peptilot charts your estimated Tirzepatide levels from the doses you actually log — in any browser, free for your first 3 days.

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