Semaglutide half-life

Semaglutide has an elimination half-life of approximately 165 hours (about 6.9 days). Here is what that means for how long a single dose stays in your system.

Simple single‑compartment elimination model ((1/2)^t/t½): it ignores absorption, route, and individual variation, so treat it as a shape, not a measurement. In the Peptilot app this curve is stacked across your actual logged doses.

Clearance milestones

Milestone	Time after a single dose
50% eliminated	~6.9 days
75% eliminated	~13.8 days
90% eliminated	~23 days
~97% eliminated (≈5 half-lives)	~34 days

Evidence and source context

Regulatory status: FDA-approved prescription medicine in specific products and indications; product labels and availability vary by market.
Evidence status: Official prescribing information and a large human clinical evidence base.
Half-life context: The approximately one-week value describes terminal elimination after subcutaneous semaglutide. This page's simple curve does not model absorption, oral formulation differences, dose history, or individual variability.

Primary and official sources

Wegovy (semaglutide) prescribing informationU.S. Food and Drug Administration · Official label

Sources checked July 24, 2026 by the Peptilot editorial team. Independent medical review is pending; this page is educational and is not a treatment recommendation for Semaglutide.

About Semaglutide

Semaglutide is a long-acting GLP-1 receptor agonist that has been widely studied for blood-glucose regulation in type 2 diabetes and for effects on appetite and body weight. Its extended half-life supports commonly reported once-weekly use. This entry is informational and is not a recommendation to use the compound.

See the full Semaglutide compound page or the Semaglutide reconstitution calculator, or compare against other compounds on the half-life overview.

Questions, answered.

What is Semaglutide's half-life?

Semaglutide's elimination half-life is approximately 165 hours (about 6.9 days), based on published pharmacokinetic data. That means about half of a dose is eliminated in that time, half of the remainder in the next interval, and so on.

How long does Semaglutide stay in your system?

Using the ~5-half-lives rule of thumb, a single dose of Semaglutide is roughly 97% eliminated after ~34 days. Actual clearance varies with dose history, route, and individual metabolism — treat this as an educational estimate, not a measurement.

Do levels build up with repeated doses?

Yes — if a new dose lands before the previous one is eliminated, the remainders stack. With consistent dosing, estimated levels reach steady state after roughly four to five half-lives. Peptilot's Levels feature stacks this exact curve across your logged doses so you can see the estimate for your own history.

Educational information for people who track their protocols — not medical advice, and never a recommendation to use any compound. Always work with a qualified healthcare provider.

Peptilot charts your estimated Semaglutide levels from the doses you actually log — in any browser, free for your first 3 days.

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