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Semaglutide

Also known as: Ozempic, Wegovy, Rybelsus

Semaglutide is a long-acting GLP-1 receptor agonist that has been widely studied for blood-glucose regulation in type 2 diabetes and for effects on appetite and body weight. Its extended half-life supports commonly reported once-weekly use. This entry is informational and is not a recommendation to use the compound.

At a glance

CategoryGLP-1 & Incretins
Classglp1-agonist, incretin
Half-life165 hours (about 6.9 days)
Typical routesubcutaneous
Common vial strengths2 mg, 5 mg, 10 mg
StorageCommonly stored refrigerated; reconstituted solutions are typically kept cold and protected from light.

Evidence and source context

Regulatory status
FDA-approved prescription medicine in specific products and indications; product labels and availability vary by market.
Evidence status
Official prescribing information and a large human clinical evidence base.
Half-life context
The approximately one-week value describes terminal elimination after subcutaneous semaglutide. This page's simple curve does not model absorption, oral formulation differences, dose history, or individual variability.

Primary and official sources

  1. Wegovy (semaglutide) prescribing informationU.S. Food and Drug Administration · Official label

Sources checked July 24, 2026 by the Peptilot editorial team. Independent medical review is pending; this page is educational and is not a treatment recommendation for Semaglutide.

Elimination curve

100%50%25%12.5%6.91421280days after a single dose
Simple single‑compartment elimination model ((1/2)t/t½): it ignores absorption, route, and individual variation, so treat it as a shape, not a measurement. In the Peptilot app this curve is stacked across your actual logged doses.

Full clearance milestones on the Semaglutide half-life page.

Doing the vial math? The Semaglutide reconstitution calculator converts mg to insulin-syringe units, free and without an account.

Questions, answered.

What is Semaglutide?
Semaglutide is a long-acting GLP-1 receptor agonist that has been widely studied for blood-glucose regulation in type 2 diabetes and for effects on appetite and body weight. Its extended half-life supports commonly reported once-weekly use. This entry is informational and is not a recommendation to use the compound.
What is Semaglutide's half-life?
Semaglutide's elimination half-life is approximately 165 hours (about 6.9 days), per published pharmacokinetic data. After about five half-lives (~825 hours (about 34 days)), a single dose is roughly 97% eliminated. Individual clearance varies.
Is Semaglutide the same as Ozempic or Wegovy or Rybelsus?
Ozempic and Wegovy and Rybelsus are brand-name medicines whose active ingredient is semaglutide. People commonly track their prescribed brand under the semaglutide entry.
What do people log alongside Semaglutide?
People tracking this compound often log gastrointestinal tolerance, appetite, and body weight over time. Peptilot has one-tap logging for doses, side effects, weight, and injection sites, so patterns show up in your own record.

Educational information for people who track their protocols — not medical advice, and never a recommendation to use any compound. Always work with a qualified healthcare provider.

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