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MOTS-c half-life

MOTS-c has an elimination half-life of approximately about 30 minutes. Here is what that means for how long a single dose stays in your system.

100%50%25%12.5%3060901200minutes after a single dose
Simple single‑compartment elimination model ((1/2)t/t½): it ignores absorption, route, and individual variation, so treat it as a shape, not a measurement. In the Peptilot app this curve is stacked across your actual logged doses.

Clearance milestones

MilestoneTime after a single dose
50% eliminated~30 min
75% eliminated~1 h
90% eliminated~1.7 h
~97% eliminated (≈5 half-lives)~2.5 h

About MOTS-c

MOTS-c is a mitochondrial-derived peptide studied primarily in preclinical research on exercise capacity, metabolism, and insulin sensitivity. It is widely regarded as a research compound. This entry is informational and is not a recommendation to use the compound.

See the full MOTS-c compound page or the MOTS-c reconstitution calculator, or compare against other compounds on the half-life overview.

Questions, answered.

What is MOTS-c's half-life?
MOTS-c's elimination half-life is approximately about 30 minutes, based on published pharmacokinetic data. That means about half of a dose is eliminated in that time, half of the remainder in the next interval, and so on.
How long does MOTS-c stay in your system?
Using the ~5-half-lives rule of thumb, a single dose of MOTS-c is roughly 97% eliminated after ~2.5 h. Actual clearance varies with dose history, route, and individual metabolism — treat this as an educational estimate, not a measurement.
Do levels build up with repeated doses?
Yes — if a new dose lands before the previous one is eliminated, the remainders stack. With consistent dosing, estimated levels reach steady state after roughly four to five half-lives. Peptilot's Levels feature stacks this exact curve across your logged doses so you can see the estimate for your own history.

Educational information for people who track their protocols — not medical advice, and never a recommendation to use any compound. Always work with a qualified healthcare provider.

Peptilot charts your estimated MOTS-c levels from the doses you actually log — in any browser, free for your first 3 days.

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