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Melanotan II half-life

Melanotan II has an elimination half-life of approximately 1 hour. Here is what that means for how long a single dose stays in your system.

100%50%25%12.5%12340hours after a single dose
Simple single‑compartment elimination model ((1/2)t/t½): it ignores absorption, route, and individual variation, so treat it as a shape, not a measurement. In the Peptilot app this curve is stacked across your actual logged doses.

Clearance milestones

MilestoneTime after a single dose
50% eliminated~1 h
75% eliminated~2 h
90% eliminated~3.3 h
~97% eliminated (≈5 half-lives)~5 h

About Melanotan II

Melanotan II is a synthetic melanocortin-receptor agonist that has been studied for its effects on skin pigmentation and is widely regarded as a research compound that is not approved for general use. Reported effects also include changes in appetite and other melanocortin-mediated responses. This entry is informational and is not a recommendation to use the compound.

See the full Melanotan II compound page or the Melanotan II reconstitution calculator, or compare against other compounds on the half-life overview.

Questions, answered.

What is Melanotan II's half-life?
Melanotan II's elimination half-life is approximately 1 hour, based on published pharmacokinetic data. That means about half of a dose is eliminated in that time, half of the remainder in the next interval, and so on.
How long does Melanotan II stay in your system?
Using the ~5-half-lives rule of thumb, a single dose of Melanotan II is roughly 97% eliminated after ~5 h. Actual clearance varies with dose history, route, and individual metabolism — treat this as an educational estimate, not a measurement.
Do levels build up with repeated doses?
Yes — if a new dose lands before the previous one is eliminated, the remainders stack. With consistent dosing, estimated levels reach steady state after roughly four to five half-lives. Peptilot's Levels feature stacks this exact curve across your logged doses so you can see the estimate for your own history.

Educational information for people who track their protocols — not medical advice, and never a recommendation to use any compound. Always work with a qualified healthcare provider.

Peptilot charts your estimated Melanotan II levels from the doses you actually log — in any browser, free for your first 3 days.

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