PeptilotOpen the web app — 3 days free

Sermorelin half-life

Sermorelin has an elimination half-life of approximately about 12 minutes. Here is what that means for how long a single dose stays in your system.

100%50%25%12.5%122436480minutes after a single dose
Simple single‑compartment elimination model ((1/2)t/t½): it ignores absorption, route, and individual variation, so treat it as a shape, not a measurement. In the Peptilot app this curve is stacked across your actual logged doses.

Clearance milestones

MilestoneTime after a single dose
50% eliminated~12 min
75% eliminated~24 min
90% eliminated~40 min
~97% eliminated (≈5 half-lives)~1 h

About Sermorelin

Sermorelin is a growth-hormone-releasing hormone (GHRH) analog corresponding to the first 29 amino acids of GHRH, studied for its ability to stimulate the body's own growth-hormone production. It has a very short half-life. This entry is informational and is not a recommendation to use the compound.

See the full Sermorelin compound page or the Sermorelin reconstitution calculator, or compare against other compounds on the half-life overview.

Questions, answered.

What is Sermorelin's half-life?
Sermorelin's elimination half-life is approximately about 12 minutes, based on published pharmacokinetic data. That means about half of a dose is eliminated in that time, half of the remainder in the next interval, and so on.
How long does Sermorelin stay in your system?
Using the ~5-half-lives rule of thumb, a single dose of Sermorelin is roughly 97% eliminated after ~1 h. Actual clearance varies with dose history, route, and individual metabolism — treat this as an educational estimate, not a measurement.
Do levels build up with repeated doses?
Yes — if a new dose lands before the previous one is eliminated, the remainders stack. With consistent dosing, estimated levels reach steady state after roughly four to five half-lives. Peptilot's Levels feature stacks this exact curve across your logged doses so you can see the estimate for your own history.

Educational information for people who track their protocols — not medical advice, and never a recommendation to use any compound. Always work with a qualified healthcare provider.

Peptilot charts your estimated Sermorelin levels from the doses you actually log — in any browser, free for your first 3 days.

Open the web app — 3 days freeLearn more about Peptilot