The Association Between Serum MOTS-c Levels and Myocardial Ischemia-Reperfusion Injury in Patients with Acute Myocardial Infarction: A Cross-Sectional Study.
This cross-sectional study investigated the relationship between serum levels of MOTS-c — a mitochondria-derived peptide encoded in the 12S rRNA — and myocardial ischemia-reperfusion injury (MIRI) in patients with acute myocardial infarction (AMI) undergoing percutaneous coronary intervention (PCI). Seventy-two AMI patients were divided into MIRI (n=34) and non-MIRI (n=38) groups. The study measured MOTS-c concentrations in both peripheral serum and intracoronary blood, alongside clinical variables. The MIRI group displayed lower systolic blood pressure, lower pre-operative TIMI grade, and lower HDL-C, while showing higher total ischemic time, door-to-balloon time, culprit vessel stenosis severity, Killip grade, and adverse event rates. Multivariate logistic regression identified postoperative peripheral serum MOTS-c as an independent protective factor against MIRI, and ROC analysis suggested potential predictive value for MIRI. Limitations include the small sample size, single-center cross-sectional design, lack of causal inference, and the absence of dynamic longitudinal monitoring of MOTS-c. The authors conclude that MOTS-c warrants further investigation as a novel biomarker and potential therapeutic target for MIRI, pending validation in larger prospective studies.
Why this grade: Cross-sectional design with a small sample (n=72), single center, and no causal inference or longitudinal follow-up limit the strength of conclusions for human efficacy.
Background/Objectives : Percutaneous coronary intervention (PCI) effectively restores coronary flow in acute myocardial infarction (AMI), but myocardial ischemia-reperfusion injury (MIRI) remains a major prognostic determinant. Mitochondrial open reading frame of the 12S rRNA-c (MOTS-c) has shown cardiovascular protective effects, yet its association with MIRI is unclear. This study aimed to investigate the relationship between serum MOTS-c levels and MIRI in AMI patients. Methods : Seventy-two AMI patients undergoing PCI were enrolled and divided into MIRI ( n = 34) and non-MIRI ( n = 38) groups. Clinical data and MOTS-c levels in peripheral serum and intracoronary blood were compared. Multivariate logistic regression and receiver operating characteristic (ROC) analysis were performed to identify MIRI predictors. Results : The MIRI group exhibited lower systolic blood pressure, preoperative thrombolysis in myocardial infarction (TIMI) grade, and HDL-C, but higher total ischemic time, door-to-balloon time, culprit vessel stenosis severity, Killip grade and adverse event incidence (all p p Conclusions : Postoperative peripheral serum MOTS-c levels represent an independent protective factor against MIRI in patients with acute myocardial infarction and suggest a potential predictive value for MIRI, although its clinical utility as a standalone predictor requires further validation through dynamic monitoring and larger-scale studies. This finding may offer a potential novel biomarker and therapeutic direction for MIRI.
Educational summary of published research — not medical advice. License: cc by. Full text is shown only where licensing permits.